The vaccination will be made available to 17 and 18-year-olds across Cardiff and the Vale of Glamorgan, as a result of recent outbreaks of meningitis.
Meningococcal group B (MenB) bacteria can cause life-threatening illnesses such as meningitis and septicaemia.
Dr Claire Beynon, executive director of public health at Cardiff and Vale University Health Board, said: “Meningococcal disease can develop very quickly and, although rare, it can have devastating consequences for individuals and families.
“Vaccination is the best way to protect yourself against MenB infection.
“We strongly encourage everyone who is eligible to take up the offer of vaccination and ensure they receive both doses, particularly those preparing to start university or college, where living and socialising in close contact with others can increase the risk of infection.”
Appointment letters will be sent to those born between September 1, 2007, and August 31, 2008.
Vaccinations will be given at Maelfa Wellbeing Hub in Llanedeyrn, Barry Hospital, and Riverside Health Centre.
The first dose will be offered from late July, with a second dose to follow four weeks later.
This is a targeted programme, and only those within the specified age group will be eligible.
